생물공학

• 기능성 식품학
• 향장 생물공학

• 강상모 외3. (2007) 제니스테인에 의한 노화된 피부세포 활성화와 콜라겐 생성 효과. 한국미생물·생명공학회지
• 강상모 외3. (2007) 돼지감자의 이눌린, 연잎, 허브의 병합식이가 고지방식이로 유도된 비만흰쥐에 미치는 영향.한국응용생명화학회지
• 강상모 외4. (2008) 제니스테인의 멜라닌 생성 억제 및 In vivo 미백 효과. Journal of Microbiology and Biotechnology
• 강상모 외1. (2008) 돈피 추출 콜라겐 보충 식이가 중년 여성의 혈중 콜라겐, 성호르몬, 지질대사 및 피부 갈라짐에 미치는 영향.대한지역사회영양학회지
• 강상모 외2. (2008)알러지성 천식 모델 생쥐에서 프랑킨세스 에센셜 오일의 염증 억제 효과.한국미생물·생명공학회지
• 강상모 외2. (2008) 국화류 추출물의 항산화 및 멜라닌 생성 억제 활성.한국응용생명화학회지
• 강상모 외2. (2008) 마우스에서 vltkamin E의 장단기적인 항스트레스 효과.한국미생물·생명공학회지 (2009) Kang SM, Koh J, Noh SY, et. Effects of lugworm protease on the dyeing properties of protein fibers, Journal of Industrial and Engineering Chemistry. (2009)
• 강상모 외3, Quality Improvement of the Human Hair by the Treatment of Protease Extracted from Earthworm, 한국염색가공학회지.
• 강상모 외2. (2008)알러지성 천식 모델 생쥐에서 프랑킨세스 에센셜 오일의 염증 억제 효과.한국미생물·생명공학회지
• 강상모 외2. (2008) 국화류 추출물의 항산화 및 멜라닌 생성 억제 활성.한국응용생명화학회지
• 강상모 외2. (2008) 마우스에서 vltkamin E의 장단기적인 항스트레스 효과.한국미생물·생명공학회지

• 생물에너지 실험실 (Bioenergy Laboratory)
• Bioenergy 생산 관련 연구
• 식물용 Biosensor 제작
• Microbial fuel cell 관련 연구
• Bioelectrochemistry 관련 연구
• 식물 이용 미세먼지 제거 기술
• Wine 기기분석

• Yoon et al., Monitoring Plant Health Using a Plant Microbial Fuel Cell, Bulletin of the Korean Chemical Society, 2018, 39(10), 1193~1197.
• Kim et al., Phytoremitation of volatile organic compounds by indoor plants;a review, Horiticulture Envrionmnet and Biotechnology, 2018, 59(2), 143~157.
• Kumaran et al., Green Synthesis of Silver Nanoparticles Using Ginkgo bilona and Their Bactericidal and Larvicidal Effects, Nanoscience and Nanotechnology Letters, 2018, 10(3), 422~428.
• Chang et al., Effect of Electrical Ground Connection on Plant Growth, Bulletin of the Korean Chemical Society, 2017, 38(12), 1491~1494.
• Choi et al.,Enhanced Growth and Total Fatty Acid Production of Microalgae Under Various Lighting Conditions Induced by Flashing Light, Engineering in Life Sciences, 2017, 17(9), 976~980.
• Kumaran at al., An in vitro Study on the Burn Wound Healing Activity of Cotton Fabrics Incorporated with Phytosynthesized Silver Nanoparticles in Male Wistar Albino rats, European Journal of Pharmaceutical Sciences, 2017, 100, 187~196.
• Kim et al., Alginate/Bacterial Cellulose Nanocomposite beads prepared using Gluconacetobacter xylinus and their application in lipase Immobilization, Carbohydrate Polymers, 2017, 157, 137~145.

• 효소공학 연구실 (Enzyme Engineering Laboratory)

효소공학 연구실에서는 효소를 이용한 다양한 화학반응과 이의 응용에 대하여 연구합니다. 효소는 화학선택성, 구조선택성, 입체선택성 등의 기질특이성과 낮은 반응온도 등의 특징을 가지고 있으며, 물에서 뿐 아니라 다양한 용매에서 화학반응을 선택적으로 촉진합니다. 또한, 최근 나노기술의 발전은 효소의 안정성을 크게 향상시킴으로써, 효소의 응용 가능성을 확대하는 계기가 되었습니다. 본 연구실에서는 효소를 이용한 바이오 에너지 생산, 생물연료전지의 개발, 나노 바이오촉매의 개발 등을 수행하고자 합니다.

• S. H. Lee, T. V. Doherty, R. J. Linhardt, and J. S. Dordick, “Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis” Biotechnology and Bioengineering (2009) 102: 1368.
• T. J. Simmons, S. H. Lee, T. J. Park, D. P. Hashima, P. M. Ajayan, and R. J. Linhardt, “Antiseptic single wall carbon nanotube bandages” Carbon (2009) 47: 1561.
• S. H. Lee, S. H. Ha, and Y. –M. Koo, “Influence of ionic liquids under controlled water activity and low halide content on lipase activity” Korean Journal of Chemical Engineering (2008) 25: 1456.
• S. H. Lee and S. B. Lee, “Octanol-water partition coefficients of ionic liquids” Journal of Chemical Technology and Biotechnology (2008) 84: 202.
• T. J. Park, S. H. Lee, T. J. Simmons, J. G. Martin, S. A. Mousa, E. A. Snezhkova, V. V.
• Sarnatskaya, V. G. Nikolaev, and R. J. Linhardt, “Heparin–cellulose–charcoal composites for drug detoxification prepared using room temperature ionic liquids” Chemical Communications (2008) 5022.
• S. H. Lee, N. M. Hiep, Y. –M. Koo, and S. H. Ha, “Ultrasound-enhanced lipase activity in the synthesis of sugar ester using ionic liquids” Process Biochemistry (2008) 43: 1009.
• S. H. Ha, S. H. Lee, D. T. Dang, W. –J. Chang, Y. J. Yu, I. S. Byun, and Y. –M. Koo, “Enhanced stability of Candida antarctica lipase B in ionic liquids” Korean Journal of Chemical Engineering (2008) 25: 291.
• S. H. Lee, S. H. Ha, N. M. Hiep, W. –J. Chang, Y. –M. Koo, “Lipase-catalyzed synthesis of glucose fatty acid ester using ionic liquids mixtures” Journal of Biotechnology (2008) 133: 486.

• 자연계에 존재하는 다양한 미생물 및 공업용 효소를 이용, 유용한 생화학 물질 (정밀화학 물질, 단백질, 탄수화물, 대사물질 등을 중심으로)의 대량 생산.
• 조절 유전자 발현 연구 및 생리의 정량적 이해, 새로운 반응의 디자인, 조업 최적화와 그의 공학적 해석.
• 대사공학기술, 유전체학, 단백체학, 생물정보학, 시스템 생물학 등의 새로운 기법을 통해 미생물계를 새롭게 재해석.
• 신규 효소의 발굴과 효소반응의 예측가능한 방법론의 연구.

• Hong et al., An alternative method for utilizing dumped egg yolk by extracting oil and producing Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) Journal of Microbiology and Biotechnology, In print
• Hong et al., Polyhydroxybutyrate production in halophilic marine bacteria Vibrio proteolyticus isolated from the Korean peninsula Bioprocess and Biosystems Engineering In print
• Lee et al., The pH-stat butyric acid feeding strategy coupled with gas-stripping for n-butanol production by Clostridium beijerinckii Waste and Biomass Valorization In print
• Park et al, Choi Ecofriendly one-pot biosynthesis of indigo derivative dyes using CYP102G4 and PrnA halogenase Dyes and Pigments 2019 March; 162: 80-88
• Gurav et al., Yang One-pot exploitation of chitin biomass for simultaneous production of electricity, n-acetylglucosamine and polyhydroxyalkanoates in microbial fuel cell using novel marine bacterium Arenibacter palladensis YHY2 Journal of Cleaner Production Volume 209, 1 February 2019, Pages 324-33
• Gurav et al., Bioconversion of plant biomass hydrolysate into bioplastic (polyhydroxyalkanoates) using Ralstonia eutropha 5119 Bioresour Technol. 2019 Jan;271:306-315.
• Vyavahare et al.,Strategies for crystal violet dye sorption on biochar derived from mango leaves and evaluation of residual dye toxicity Journal of Cleaner Production 2019 January 10, 207: 296-305
• Lee et al., Development of novel on-line capillary gas chromatography-based analysis method for volatile organic compounds produced by aerobic fermentation. J Biosci Bioeng. 2019 Jan;127(1):121-127

• Nucleic acid bioengineering
• Point-of-care diagnostic system for infectious disease
• Exosome-based cancer diagnostics Nano biotechnology for biomedical sensing

• Lee et al.,"Sensitive detection of DNA from Chlamydia trachomatis by using flap endonuclease-assisted amplification and graphene oxide-based fluorescence signaling", Microhimica acta [IF=5.705], Accepted (2019)
• Ahn et al.,"Food waste-driven N-doped carbon dots: Applications for Fe3+ sensing and cell imaging", Materials Science and Engineering: C [IF=5.080], Accepted (2019)
• Kalimuthu et al., A simple approach for rapid and cost-effective quantification of extracellular vesicles using a fluorescence polarization technique", Journal of Biological Engineering [IF=5.256], Accepted (2019).
• Lee et al., “Fluorescent S1 nuclease assay utilizing exponential strand displacement amplification", Analyst [IF=3.864], Accepted (2019).
• Eun et al., “Melamine-promoted formation of bright and stable DNA-silver nanoclusters and their antimicrobial properties”, Journal of Materials Chemistry B [IF=4.776], Accepted (2019).
• Jung et al., "Target-activated DNA polymerase activity for sensitive RNase H activity assay", Biotechnology Journal [IF=3.507], Accepted (2019).
• Jeong et al., "Fluorescence, turn-on detection of melamine based on its dual functions as fluorescence enhancer of DNA-AgNCs and Hg(II)-scavenger", Artificial cells, Nanomedicine, and Biotechnology [IF=3.026], 47(1), 621-625 (2019).
• Baek et al.,"A one-step and label-free, electrochemical DNA detection using metal ion-mediated molecular beacon probe", Electrochemistry Communications [IF=4.66], 100, 64-69 (2019).
• Jung et al., "Sensitive and specific detection of proteins based on target-responsive DNA polymerase activity", Analytica Chimica Acta [IF=5.123], 1059, 80-85 (2019).
• Jang et al.,"Flap endonuclease-initiated enzymatic repairing amplification for ultrasensitive detection of target nucleic acids", Nanoscale [IF=7.367], 11(8), 3633=3638 (2019).